Abcam, ab250062, Anti-STARD5 antibody [EPR13545(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal STARD5 antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13545(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250062 is the carrier-free version of
ab178688
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STARD5 also known as StAR-related lipid transfer domain protein 5 is an important player in intracellular cholesterol transport. It functions as a START domain containing protein facilitating the transfer of cholesterol and other lipids between intracellular membranes. With a molecular mass of approximately 23 kDa STARD5 displays a specific pattern of expression in tissues. It is highly expressed in the liver kidney and spleen where it plays a role in cellular lipid regulation.
Biological function summary
The transfer of cholesterol and lipids by STARD5 helps maintain cellular lipid homeostasis. It is not known to form part of a complex but operates independently to ensure that cholesterol levels are balanced within cells. This activity supports cell membrane integrity and the synthesis of steroid hormones and bile acids. By regulating these processes STARD5 plays a significant function in maintaining cell health and metabolism.
Pathways
The activity of STARD5 is critical in the cholesterol transport and metabolism pathway. It works closely with proteins such as NPC1 and NPC2 which also facilitate cholesterol trafficking. This involvement aligns STARD5 with the lysosomal storage pathway highlighting its role in managing cholesterol storage and mobilization within cells.
Altered function or expression of STARD5 links to conditions like Niemann-Pick disease type C and obesity-related dyslipidemia. Niemann-Pick disease type C is closely tied to disrupted cholesterol transport where STARD5's role intersects with NPC1 and NPC2 proteins both known for their involvement in this lysosomal disorder. In obesity-related dyslipidemia the protein's regulation of cholesterol levels can impact lipid profiles influencing disease development and progression.