Abcam, ab250243, Anti-TSPAN17 antibody [EPR9855(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TSPAN17 antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9855(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250243 is the carrier-free version of
ab180601
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TSPAN17 also known as tetraspanin-17 is a member of the tetraspanin family of proteins. It functions mechanically as a membrane-associated protein with four transmembrane domains. The protein has a molecular weight of approximately 25 kDa. Expression of TSPAN17 occurs broadly in various tissues with a notable presence in the central nervous system and immune cells. This protein plays a role in cell signaling by forming complexes with other cell surface receptors.
Biological function summary
TSPAN17 contributes to the orchestration of cell motility and interaction processes. It is a part of the tetraspanin-enriched microdomain which facilitates the lateral organization of distinct protein complexes at the cell membrane. These complexes support processes like cell adhesion and migration suggesting TSPAN17 participation in cellular communication and signaling pathways. The involvement in these processes highlights its role in maintaining cellular dynamics and response to external stimuli.
Pathways
TSPAN17 integrates into pathways governing cell adhesion and immune response. It interacts with proteins within the integrin signaling pathway important for facilitating cell-matrix interactions and coordinating immune system activity. Through its association with integrins TSPAN17 aids in linking extracellular matrix signals to intracellular cascades like those involving phosphatidylinositol 3-kinase (PI3K) affecting cellular responses to environmental changes.
Research links TSPAN17 to neurological disorders and cancer. Alterations in its expression levels have emerged in studies of neurodegenerative diseases where abnormal activity affects cellular signaling. In cancer TSPAN17's interaction with tissue-invasive proteins such as matrix metalloproteinases (MMPs) links it to tumor progression and metastasis. Understanding TSPAN17's role provides insights into its potential as a therapeutic target in these complex diseases.