Abcam, ab250783, Anti-PCTP antibody [EPR15390] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PCTP antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15390,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250783 is the carrier-free version of
ab184944
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCTP also known as Phosphatidylcholine Transfer Protein is a lipid-binding protein important for lipid metabolism. It weighs approximately 26 kDa and is expressed in many tissues including liver adipose tissue and testis. Mechanically PCTP binds to phosphatidylcholine and transfers it between membranes. This transfer is essential in maintaining the lipid composition and function of cell membranes. The target enables effective lipid signaling in various cellular environments.
Biological function summary
PCTP plays a role in the management of lipid homeostasis and membrane structure. The protein does not form part of a larger complex but interacts with various membrane-associated lipid molecules. Its activity affects the distribution of lipids within cells and contributes to processes such as membrane trafficking and signal transduction. This activity supports cellular functions like proliferation differentiation and apoptosis through regulated lipid signaling.
Pathways
PCTP participates in lipid signaling and transport mechanisms. The protein associates with key pathways like glycerophospholipid metabolism and glycerolipid metabolism influencing lipid distribution and cellular communication. It interacts with proteins such as ABCA1 and LXR which play significant roles in cholesterol and phospholipid transport. These interactions help regulate lipid levels in the cell ensuring proper biological function within these pathways.
PCTP links to conditions like cardiovascular disease and metabolic syndrome. Aberrant PCTP activity can influence lipid levels and contribute to the pathogenesis of these disorders. The protein interacts with molecules like oxidized LDL in the context of cardiovascular disease impacting lipid accumulation and atherosclerosis. Understanding PCTP's role in these conditions may offer insights into therapeutic strategies targeting lipid metabolism.