Abcam, ab250938, Anti-TAGAP antibody [EPR15593] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TAGAP antibody. Carrier free. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15593,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab250938 is the carrier-free version of
ab187664
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAGAP also known as T-cell activation RhoGTPase activating protein acts as a Rho GTPase-activating protein involved in the regulation of the actin cytoskeleton. It weighs approximately 70 kDa. This protein is particularly expressed in immune cells including T-cells B-cells and dendritic cells. TAGAP plays an important role in the modulation of signaling pathways essential for immune cell activation and function.
Biological function summary
TAGAP contributes to the regulation of immune responses. It influences the rearrangement of the actin cytoskeleton affecting cell movement and activation. Though not a part of a large protein complex TAGAP's ability to manage cytoskeletal dynamics is critical in immune cells such as T-cells enabling proper response to antigens.
Pathways
TAGAP is significant in the T-cell receptor signaling and actin cytoskeleton regulation pathways. These pathways facilitate immune cell activation and migration key processes in immune response. TAGAP mediates interactions with proteins like Rac1 involved in cytoskeletal organization and Vav1 a guanine nucleotide exchange factor that activates pathways necessary for the immune response.
TAGAP's function links to autoimmune diseases like multiple sclerosis and rheumatoid arthritis. Altered TAGAP expression or function can influence disease susceptibility making it a target for research. Through autoimmune-related pathways TAGAP interacts with proteins such as IL-2 and STAT4 which are implicated in these disorders highlighting its potential role in influencing immune system balance and disease progression.