Abcam, ab251056, Anti-Cathepsin W antibody [EPR15135] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Cathepsin W antibody. Carrier free. Suitable for IP, WB and reacts with Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15135,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab251056 is the carrier-free version of
ab191083
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cathepsin W also known as CTSW is a member of the cysteine protease family. It has a molecular mass of approximately 45 kDa and functions as an enzyme that breaks down protein substrates through proteolysis. CTSW displays specificity for certain peptide bonds in its target proteins. This protein is mostly expressed in the immune system especially in cytotoxic T cells and natural killer cells. The expression pattern suggests its involvement in immune responses.
Biological function summary
Cathepsin W contributes to the modulation of cytotoxic activity. It assists in the rearrangement and processing of proteins important for the immune response facilitating the proper functioning of immune effector cells. While not part of a specific protein complex CTSW activity aligns with immune cell regulation mechanisms. Its role in the degradation of proteins plays a significant part in maintaining immune cell competency.
Pathways
Cathepsin W contributes to the immune response and apoptosis. The immune response pathway involves cytotoxic T cells and natural killer cells where CTSW enhances the degradation of target proteins. In apoptosis the protein functions in the breakdown of cellular components that need recycling or removal. Cathepsin W shares functional similarities with related proteases such as Cathepsin C which also participates in immune cell regulation and apoptosis.
Cathepsin W has relevance in immunological diseases and some cancer types. Altered activity of CTSW may associate with impaired immune responses contributing to immunodeficiency conditions. In certain cancers such as leukemia changes in CTSW expression could influence the behavior of tumor-infiltrating lymphocytes. Proteins like granzyme B which are involved in inducing apoptosis might interact with CTSW reflecting their shared pathways in modulating immune responses and disease progression.