Abcam, ab251658, Anti-Homeobox protein SIX6 antibody

Size: 100µL
Rabbit Polyclonal Homeobox protein SIX6 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SIX6 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SIX6 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95475

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Homeobox protein SIX6 also known as Optx2 or Six9 plays an important role in developmental processes. It is a part of the SIX homeobox family of transcription factors and has a molecular mass of approximately 29 kDa. SIX6 influences the formation and differentiation of specific tissues especially in the eye and brain. This protein is expressed in the retina pituitary gland and forebrain of developing organisms indicating its involvement in early developmental stages and neuronal development.
Biological function summary
SIX6 influences the regulation of gene expression essential for proper eye and retinal development. It acts as a transcription factor meaning it binds to DNA and modulates transcription of particular target genes. While it is not part of a larger complex SIX6 still interacts with cofactors to exert precise control over genetic programs during development. Its expression ensures that specific cellular pathways are activated or repressed essential for proper differentiation and tissue morphogenesis.
Pathways
SIX6 is central to the Wnt signaling pathway and the Sonic Hedgehog signaling pathway both of which are important for cell differentiation and proliferation. In these pathways SIX6 works with other proteins such as beta-catenin facilitating the activation of genes important for tissue patterning. SIX6 interplays with transcription factors like Pax6 which together guide the developmental processes of optic and neuroectodermal tissues highlighting its strategic position in early developmental signaling cascades.
SIX6 has been linked to ocular diseases and brain development disorders. Mutations or dysregulation of SIX6 are associated with aniridia a rare eye disorder and optic nerve hypoplasia which leads to vision impairment. Additionally its aberrant expression can connect with other proteins like PAX6 in these disorders where both are important for eye development thereby compounding developmental anomalies. Understanding the function and regulation of SIX6 can help in unraveling the molecular basis of these conditions and in developing targeted therapeutic strategies.