Abcam, ab251797, Anti-PDSS2 antibody

Size: 100µL
Rabbit Polyclonal PDSS2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDSS2 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PDSS2 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q86YH6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDSS2 also known as decaprenyl-diphosphate synthase subunit 2 is an enzyme that plays an important role in the biosynthesis of coenzyme Q (CoQ). This enzyme has a mass of approximately 43 kDa. PDSS2 is primarily expressed in the mitochondria where it participates in the process of extending the prenyl side chain of ubiquinone. Its activity is essential for the creation of isoprenoid compounds and it is involved in the synthesis of decaprenyl pyrophosphate which is an important precursor in the CoQ biosynthesis pathway.
Biological function summary
The enzyme extends the polyprenyl side chain of ubiquinone which is essential for its function in the mitochondrial electron transport chain. PDSS2 works closely with other enzymes in a multiprotein complex to ensure appropriate CoQ length and function. This activity is important for electron transport and ATP production. The enzymatic function of PDSS2 maintains mitochondrial integrity and performance by supporting oxidative phosphorylation.
Pathways
PDSS2 is involved in the ubiquinone and other terpenoid-quinone biosynthesis pathways. In these pathways PDSS2 interacts with proteins such as COQ2 which also contributes to the biosynthesis of CoQ. Together they ensure the proper synthesis of CoQ10 which is important for the mitochondrial respiratory chain pathway. This connection between PDSS2 and COQ2 highlights their collaboration in producing an important component necessary for cellular energy metabolism.
Mutations in PDSS2 have been linked to Coenzyme Q10 deficiency which can lead to mitochondrial dysfunction. This deficiency affects organs with high energy demands such as muscles and the nervous system. Additionally dysregulation of the CoQ biosynthesis pathway due to PDSS2 mutations is associated with various disorders including kidney dysfunction. PDSS2 is also related to other proteins like COQ9 which influence CoQ levels and their effect on cellular health and disease.