Abcam, ab251902, Anti-COPS6 antibody

Size: 100µL
Rabbit Polyclonal COPS6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human COPS6 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human COPS6 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7L5N1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The COPS6 also known as COP9 signalosome complex subunit 6 is a component of the COP9 signalosome (CSN) complex. It has a molecular weight of approximately 33 kDa. This protein exists mostly in the nucleus and cytoplasm of cells. COPS6 helps regulate protein degradation by participating in deneddylase activity which is important for controlling the activity and stability of proteins targeted by the ubiquitin-proteasome system.
Biological function summary
COPS6 plays a role in several cellular functions beyond deneddylation. It is an integral part of the COP9 signalosome complex which modulates protein levels and activities by regulating the neddylation state of cullins. This regulation influences processes such as signal transduction and cell cycle control. The complex influences not just protein degradation but also various other cellular mechanisms through its wide interactions.
Pathways
COPS6 participates in the ubiquitin-mediated proteolysis pathway impacting the regulation of proteasome activities. Another significant pathway involving COPS6 is the cell cycle regulation pathway where it interacts with proteins like SKP1 and CUL1. These interactions highlight the significance of COPS6 in the coordination of cellular progression and responses to external signals facilitating proper cell function and survival.
COPS6 has connections to certain cancers and inflammatory diseases. Abnormal expression or mutations of COPS6 can lead to unregulated protein turnover contributing to oncogenesis in various tissues. It demonstrates interaction with proteins such as MDM2 which can influence tumor suppressor pathways. In inflammation maladjustment of proteasome activity involving COPS6 can exacerbate conditions by affecting inflammatory signaling cascades.