Abcam, ab252962, Anti-MASA antibody

Size: 100µL
Rabbit Polyclonal MASA antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ENOPH1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ENOPH1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9UHY7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MASA protein also known simply as MASA presents a molecular mass of approximately 60 kDa. MASA is expressed predominantly in neuronal tissues with specific abundance in areas of the brain linked to cognitive functions. This protein resides within the cytoplasm and shows a strong presence in neurons suggesting its role in nervous system operations. The MASA protein has gathered significant interest in neuroscience for its contribution to cellular processes.
Biological function summary
The MASA protein plays a critical role in cellular communication within neurons. It does not generally form part of a larger protein complex but interacts directly with other proteins to modulate synaptic transmission. Researchers have demonstrated that it influences the release of neurotransmitters impacting neuronal excitability and synaptic plasticity. This protein through its actions is vital for maintaining the functional network among neural cells.
Pathways
MASA protein involves itself in signaling pathways related to synaptic function and plasticity. One of the key pathways includes the NMDA receptor pathway where MASA interacts with proteins like PSD-95. There is also significant interaction with proteins involved in the MAPK signaling pathway. The ability of MASA to influence these pathways points to its integral function in regulating synaptic strength and memory formation in the brain.
Researchers have found associations between MASA protein and certain neurodegenerative diseases. Alzheimer's disease presents strong connections with MASA as the protein appears to influence amyloid-beta processing. In addition the MASA protein has possible links to schizophrenia potentially connected through its interactions with disrupted-in-schizophrenia-1 (DISC1) proteins. These relationships highlight MASA as a potential target for therapeutic strategies aimed at treating neurological disorders.