Abcam, ab252986, Anti-CCRK antibody

Size: 100µL
Rabbit Polyclonal CCRK antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDK20 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CDK20 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q8IZL9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCRK or Cell Cycle-Related Kinase is a protein kinase with significant roles in cellular processes. It is also referred to as CDK20 (Cyclin-Dependent Kinase 20) and possesses a molecular mass of approximately 39 kDa. Researchers observe CCRK expression mainly in human tissues such as the brain heart and testis. This protein exhibits activity in regulating various stages of the cell cycle and phosphorylation of target substrates during cell division.
Biological function summary
This protein plays a role in facilitating cell cycle progression and cellular proliferation. CCRK often associates with other cyclins to form active complexes necessary for its kinase activity. The protein's interaction with cyclins emphasizes its ability to drive cells through different phases of the cell cycle. Aside from cell cycle control CCRK also influences ciliogenesis suggesting a broader range of biological functions.
Pathways
CCRK integrates into specific cellular pathways including the cell cycle control and Wnt signaling pathways. In the cell cycle pathway CCRK influences progression at critical checkpoints interacting with related proteins like Cyclin D1. In the context of Wnt signaling CCRK may modulate signaling outputs influencing downstream gene expression events. These interactions align CCRK with key regulatory networks essential for maintaining normal cellular physiology.
CCRK shows involvement in conditions such as cancer and ciliopathies. In several cancers aberrant expression or activity of CCRK contributes to uncontrolled cell proliferation due to interactions with proteins like Cyclin D1 which in turn drive oncogenic signaling. As for ciliopathies CCRK-related dysfunction affects cilia formation leading to related disorders. Understanding these pathways and interactions highlights CCRK as a target for therapeutic interventions in specific diseases.