Abcam, ab254026, Mature Oligodendrocyte Marker (Olig2, MBP, MOG, SOX10) Antibody Sampler Panel - Human, Mouse

Size: 1Kit
Mature Oligodendrocyte Marker panel containing 5 rabbit monoclonal antibodies against Human and Mouse Olig2, MBP, MOG, SOX10. - Specifically selected for high performance in various applications. - Provided as a sampler panel to allow you to easily evaluate each in your required applications.
Key facts
Reacts with:Mouse, Human,
Target:OLIG2See target data

Product details:
Product Specifications
Mature Oligodendrocyte Marker (Olig2, MBP, MOG, SOX10) Antibody Sampler Panel - Human, Mouse (ab254026) is a panel of 5 rabbit recombinant monoclonal antibodies specific to markers of mature oligodendrocytes. Mature oligodendrocytes are responsible for producing myelin, which insulates neuronal axons in the central nervous system (CNS).
This panel contains antibodies to Olig2 (UniProt: Q13516), Myelin Basic Protein (UniProt: P04370), Myelin oligodendrocyte glycoprotein (UniProt: Q16653) and SOX10 (UniProt: P56693) in convenient trial sizes (20 µL) to allow for efficient and cost-effect testing of the antibodies simultaneously.
The individual antibodies included in this panel are:
Rabbit recombinant monoclonal anti-Olig2 antibody [EPR2673] (
ab109186
Rabbit recombinant monoclonal anti-Myelin Basic Protein antibody [EPR21188] (
ab218011
Rabbit recombinant monoclonal anti-Myelin oligodendrocyte glycoprotein antibody [EP4281] (
ab109746
Rabbit recombinant monoclonal anti-SOX10 antibody [EPR4007] (
ab155279
Rabbit recombinant monoclonal anti-SOX10 antibody [SP267] (
ab227680
All of these component antibodies are available for purchase individually using their corresponding abIDs.
Quality and Validation
Abcams high quality validation processes ensure each component antibody is sensitive and specific to the target protein.
All antibodies in this panel have been validated in human, mouse and rat samples in a variety of applications, and some also have reactivity in other species.
For information on the species reactivity and application validation of each antibody within the panel, please consult the individual datasheet for each antibody. Suggested dilution factor and additional information on protocols can also be found on the antibody datasheets.
Related Products
Many of our antibody clones are also available as carrier-free formulations for easy conjugation to labels of your choice, or in pre-conjugated formats. Please search the clone name for alternative formulations and related products.
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Myelin Basic Protein (MBP) is a critical component of the myelin sheath surrounding nerve fibers. It is also known as mbr or myelin oligodendrocyte. MBP is found in the central nervous system primarily expressed in oligodendrocytes where it plays a structural role in compaction of the myelin membrane. The molecular mass of human MBP commonly ranges from 18.5 kDa to 21.5 kDa depending on the isoform. Alongside MBP SOX10 and Olig2 are significant oligodendrocyte markers that play roles in the development and maintenance of oligodendrocyte identity and function. Myelin oligodendrocyte glycoprotein (MOG) further complements these proteins in stabilizing the myelin sheath.
Biological function summary
MBP and its associated proteins are essential for maintaining the stability and integrity of myelin in the central nervous system. These proteins ensure proper nerve signal transmission. While MBP is not part of a larger protein complex it interacts closely with lipids in the myelin membrane to ensure proper sheath formation. SOX10 functions as a transcription factor that is critical for the regulation of myelin genes while Olig2 is involved in the differentiation and maturation of oligodendrocytes serving as an olig2 marker and playing a pivotal role in oligodendrocyte development. These markers are used in olig2 staining for detecting oligodendrocytes.
Pathways
MBP SOX10 Olig2 and MOG play significant roles within the myelination pathway vital for establishing and maintaining proper neural connections. MBP interacts closely with other proteins involved in myelination such as myelin-associated glycoprotein (MAG) ensuring the stability and functionality of the neuronal environment. The Notch signaling pathway also engages with SOX10 and Olig2 influencing oligodendrocyte differentiation and maturation which highlights their role as oligodendrocyte markers.
MBP SOX10 Olig2 and MOG are significantly linked to multiple sclerosis (MS) and other demyelinating diseases. MS involves the immune system's attack on oligodendrocyte markers leading to degradation of the myelin sheath. MBP is often targeted in autoimmune reactions that occur in MS. Additionally congenital defects in the expression of SOX10 or Olig2 can contribute to severe myelination disorders such as leukodystrophies. The connection between these proteins and neural pathologies highlights their importance in maintaining neurological health.