Abcam, ab254235, Ryuvidine

Size: 1mg / 25mg
MW 284.3 Da, Purity >98%. Inhibits (IC 50 = 500 nM) KMT5A / SETD8 / Pr-SET7 and suppresses H4JK20 monomethylation in vitro . Weakly active against Cdk4 (IC 50 = 6 μM). Induces S-phase accumulation in HEK-293 cells. Cytotoxic towards a number of human cancer cell lines. May induce the DNA damage response.
Key facts
CAS number:265312-55-8,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:284.3 Da,
Molecular formula:C15H12N2O2S,
PubChem:481747,
Nature:Synthetic,
Solubility:DMSO: 5 mg/ml,
Biochemical name:Ryuvidine,
Biological description:Inhibits (IC50 = 500 nM) KMT5A / SETD8 / Pr-SET7 and suppresses H4JK20 monomethylation in vitro. Weakly active against Cdk4 (IC50 = 6 μM). Induces S-phase accumulation in HEK-293 cells. Cytotoxic towards a number of human cancer cell lines. May induce the DNA damage response.,
Canonical smiles:CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C,
InChi:InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3,
InChiKey:HFPLHASLIOXVGS-UHFFFAOYSA-N,
IUPAC Name:2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1808 Ryuvidine. B1808-5 is the same size as the 5 mg size of ab254235.
Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. Protect from air and light.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cdk4 also known as cyclin-dependent kinase 4 is a serine/threonine kinase with a mass of about 34 kDa. This protein plays a mechanical role in cell cycle regulation especially during the G1 phase by forming a complex with D-type cyclins. Cdk4 is expressed in various tissues notably in proliferating cells. ROR gamma a related protein functions as an orphan nuclear receptor with a role in transcriptional regulation. These proteins have overlapping yet distinct functions in cell biology.
Biological function summary
Cyclin-dependent kinase 4 drives cell cycle progression through the phosphorylation of the retinoblastoma protein (Rb) releasing E2F transcription factors to begin the S phase. Cdk4 when associated with cyclin D forms a holoenzyme complex that regulates cell cycle checkpoints. ROR gamma is not a direct part of the cell cycle but modulates gene expression involved in cellular metabolism immune response and development. It influences the transcription of target genes by binding to ROR response elements within their promoters.
Pathways
Cdk4 is integral to the G1/S transition in the cell cycle pathway. It interacts closely with proteins such as cyclin D1 p16 INK4a and Rb. The MAPK/ERK pathway influences Cdk4 activity affecting cellular proliferation. ROR gamma is part of nuclear receptor pathways influencing metabolic and immune responses. It interacts with co-activators and repressors and has connections with the NF-kB signaling pathway impacting immune cell differentiation.
Aberrant Cdk4 activity is linked to various cancers including melanoma due to its role in unchecked cellular proliferation. Mutations or dysregulation of Cdk4 can lead to tumorigenesis often in coordination with altered cyclin D1 and p16 INK4a proteins. ROR gamma variants associate with autoimmune disorders including rheumatoid arthritis by affecting immune cell function. It connects to inflammation-related proteins such as IL-17 which ROR gamma regulates highlighting its importance in immune-mediated diseases.