Abcam, ab254361, Anti-Noradrenaline transporter antibody [EPR23527-534]

Size: 20µL / 100µL / 1mL
Anti-Noradrenaline transporter antibody [EPR23527-534] (ab254361) is a rabbit monoclonal antibody detecting Noradrenaline transporter in Western Blot, Flow Cytometry, IHC-P, IHC-Fr, mIHC . Suitable for Human, Mouse, Rat . - Multiplex IHC validated on the Leica BOND® MAX using Opal reagents - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23527-534,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, mIHC, Flow Cyt, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Noradrenaline transporter antibody [EPR23527-534] (ab254361) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Multiplex IHC (mIHC) in Human, Mouse, Rat samples.
What is the molecular weight of Noradrenaline transporter?
Anti-Noradrenaline transporter [EPR23527-534] (ab254361) specifically detects a band for Noradrenaline transporter (UniProt: O55192) at a molecular weight of 69kDa.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
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Other related products
We have a range of other formats of antibody clone [EPR23527-534] also available for your convenience: ab254361, Carrier free -
ab282022
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The noradrenaline transporter also known as norepinephrine transporter (NET) is a protein that transports the neurotransmitter noradrenaline from the synaptic cleft back into the presynaptic neuron. This process is important for terminating noradrenaline signaling and maintaining neurotransmitter balance. The mass of the noradrenaline transporter is approximately 70 kDa. This transporter is mainly expressed in neuronal cells in the central and peripheral nervous systems as well as in the adrenal glands where noradrenaline plays an important role in response mechanisms.
Biological function summary
The noradrenaline transporter functions to regulate extracellular levels of noradrenaline which is essential for proper functioning of the sympathetic nervous system. It is vital in the reuptake mechanism that controls the duration and intensity of noradrenaline's action. The transporter forms part of a larger complex that involves various proteins and binding molecules that facilitate noradrenaline reuptake efficiently by ensuring synaptic concentration of needed ions.
Pathways
The activity of the noradrenaline transporter is an integral part of the adrenergic signaling pathway which is instrumental in the body's response to stress. This pathway includes complex interactions involving G protein-coupled receptors and proteins like dopamine transporter which sometimes parallel its action. The transporter is also involved in the catecholamine biosynthesis pathway which is responsible for the production and breakdown of neurotransmitters including adrenaline and dopamine.
Alterations in the expression or function of the noradrenaline transporter have been associated with conditions such as depression and attention-deficit hyperactivity disorder (ADHD). In these conditions altered transporter function can lead to neurotransmitter imbalance affecting mood and attention. Research has also indicated potential links with other proteins like serotonin transporter in mood disorders highlighting its involvement in broader neurochemical networks.