Abcam, ab254583, Anti-SNAPIN antibody

Size: 100µL
Rabbit Polyclonal SNAPIN antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SNAPIN aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SNAPIN aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95295

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNAPIN also known as SNAP25-interacting protein has an approximate mass of 15 kDa and functions mechanically by interacting with the SNARE complex an important structure in vesicular trafficking. It binds directly to the SNAP25 protein facilitating synaptic vesicle docking and neurotransmitter release at the synapse. Expression of SNAPIN is widespread throughout neuronal tissues and other cell types indicating its role in cellular communication processes.
Biological function summary
SNAPIN enhances the efficiency of synaptic transmission and vesicle fusion processes. It integrates into the SNARE complex where it stabilizes this multi-protein assembly essential for neurotransmitter release. By bridging interactions between SNAP25 and synaptic vesicles SNAPIN helps bridge essential synapse communication modulating the synaptic transmission needed for effective neuron signaling.
Pathways
SNAPIN participates in the synaptic vesicle cycle and neurotransmitter release pathways. It works closely in tandem with proteins such as Synaptotagmin and Synaptobrevin which are vital players in the SNARE complex responsible for membrane fusion. By modulating neurotransmitter release SNAPIN contributes to synaptic plasticity and response to neurological stimuli linking it to broader neurological signaling pathways.
Dysfunction of SNAPIN can relate to neurodegenerative diseases including Alzheimer's disease due to its role in neurotransmitter release and synaptic function. Misregulation of SNAPIN function might also implicate it in psychiatric disorders such as schizophrenia where synaptic communication deficits are present. Additionally its involvement with SNAP25 in the SNARE complex associates it with these diseases and potential disruptions in SNARE-associated pathways and synaptic communication.