Abcam, ab254638, Anti-RPS29 antibody

Size: 100µL
Rabbit Polyclonal RPS29 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human 40S ribosomal protein S29 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human 40S ribosomal protein S29 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P62273

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPS29 also known as Ribosomal Protein S29 is a component of the small 40S subunit of the ribosome it weighs approximately 7.5 kDa. It plays a critical role in protein synthesis by facilitating mRNA decoding and peptidyl transferase activity. This protein is ubiquitously expressed in various tissues reflecting its essential role in cellular function.
Biological function summary
Ribosomal Protein S29 is part of the ribosomal complex which is important for cellular protein production. It ensures the proper translation of mRNA into amino acid sequences influencing protein assembly. RPS29 is not only vital for generating proteins but also contributes to the regulation of cell growth and proliferation through its participation in the ribosomal structure.
Pathways
The involvement of Ribosomal Protein S29 extends to the mTOR signaling pathway which regulates cell growth protein synthesis and autophagy. It is also part of the p53 pathway influencing cellular responses to stress and DNA damage. RPS29 works in conjunction with other ribosomal proteins like RPL11 and RPS6 which also have roles in these processes ensuring the fidelity and efficiency of protein synthesis in cells.
Abnormalities in Ribosomal Protein S29 are associated with Diamond-Blackfan Anemia a rare condition characterized by defective erythropoiesis. RPS29 mutations also implicate its relation to cancer development where disruptions in protein synthesis pathways can lead to tumorigenesis. The disorder connects RPS29 to other dysregulated proteins like p53 highlighting the impact of ribosomal dysfunction in disease progression.