Abcam, ab254751, Anti-PGAP3 antibody

Size: 100µL
Rabbit Polyclonal PGAP3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PGAP3 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PGAP3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q96FM1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target PGAP3 also called post-GPI attachment to proteins 3 is a protein involved in the processing of glycosylphosphatidylinositol (GPI) anchors. It is encoded by the PGAP3 gene and has a molecular mass of around 104 kDa. This protein expresses highly in various tissues especially in the brain and testis. PGAP3 plays an important role in the correct remodeling of GPI anchors which are critical for the stable attachment of proteins to the cell membrane.
Biological function summary
PGAP3 removes unsaturated fatty acids from GPI anchors' lipid tails allowing the addition of saturated fatty acids. This process is essential for the function and stability of GPI-anchored proteins. Although not a member of a large protein complex PGAP3 works closely with other enzymes involved in GPI-anchor maturation. The remodeling of GPI anchors by PGAP3 ensures that proteins can adhere properly to the cell membrane and perform their functions.
Pathways
The correct localization of GPI-anchored proteins depends heavily on PGAP3 function. The protein plays an important role in the GPI-anchor biosynthesis pathway and changes in PGAP3 activity affect this pathway significantly. The remodeling of GPI anchors connects PGAP3 to proteins like PIG-N which also participates in this biosynthesis process. By ensuring the correct GPI anchor assembly PGAP3 helps maintain cellular communication and signaling pathways.
Alterations in PGAP3 function associate with conditions such as intellectual disability and GPI-anchor deficiency syndrome. Mutations in the PGAP3 gene disrupt normal GPI-anchor maturation leading to a range of developmental and neurological abnormalities. The protein is also linked with PIGT another enzyme involved in the GPI biosynthesis pathway implicating these proteins in the onset of specific disorders when disrupted. Understanding the role of PGAP3 in these diseases aids in developing potential targeted therapies.