Abcam, ab254796, Anti-SNRNP40 antibody

Size: 100µL
Rabbit Polyclonal SNRNP40 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SNRNP40 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SNRNP40 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96DI7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNRNP40 also known as U5-40K or Splicing Factor 40 kDa is a component of the U5 small nuclear ribonucleoprotein complex. It has a mass of approximately 40 kDa. SNRNP40 is mainly expressed in the nucleoplasm of eukaryotic cells where it plays a critical role in RNA processing.
Biological function summary
SNRNP40 participates in the pre-mRNA splicing process as part of the spliceosome a large and dynamic ribonucleoprotein complex. The spliceosome facilitates the removal of introns from pre-mRNA transcripts. SNRNP40 as a part of this complex influences the conformational changes necessary for the accurate assembly and function of the spliceosome. Through this action SNRNP40 helps maintain genomic stability and proper gene expression.
Pathways
SNRNP40's role in the spliceosome places it within essential RNA processing pathways including the mRNA splicing pathway. It interacts with other proteins such as PRPF8 and EFTUD2 (also known as Snu114) which are key components of the U5 particle. These interactions illustrate how SNRNP40's activity is integral to the functioning of the spliceosomal machinery.
SNRNP40 has been connected to certain genetic conditions through its role in RNA splicing. Defects in the splicing process can result in splicing-related disorders such as retinitis pigmentosa although SNRNP40 itself is not directly implicated in this disease. However it shares functional associations with proteins like PRPF31 which is linked to such disorders. Additionally SNRNP40 may play a role in cancer development due to its involvement in mis-splicing events affecting tumor suppressor genes and oncogenes.