Abcam, ab254804, Anti-EXOC8 antibody

Size: 100µL
Rabbit Polyclonal EXOC8 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Exocyst complex component 8 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Exocyst complex component 8 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q8IYI6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EXOC8 also known as Exocyst complex component 8 is a protein that plays an essential role in vesicle trafficking processes. With a molecular mass of approximately 100 kDa EXOC8 forms part of the exocyst complex involved in targeting vesicles to specific sites on the plasma membrane. This protein prominently expresses in a variety of tissues including brain liver and kidney suggesting a broad functional relevance across different biological systems.
Biological function summary
EXOC8 contributes to the regulation of exocytic pathways mediating intracellular transport and secretion processes. As a core component of the exocyst complex EXOC8 works closely with other exocyst components to facilitate the tethering of secretory vesicles to precise docking sites on the cell membrane. This positioning enables efficient exocytosis and maintains cell homeostasis playing an important role in cellular signaling and membrane protein recycling.
Pathways
EXOC8 integrates within cellular mechanisms such as the exocyst-mediated vesicular targeting pathway and the Rab GTPase signaling pathway. The protein coordinates with other exocyst components like EXOC1 and SEC5 to direct specific vesicles to their target locations essential for processes like cell growth and differentiation. The pathway interactions indicate strong cooperation between these proteins ensuring the accuracy and efficiency of vesicle transport.
Several studies link EXOC8 to conditions such as cancer and diabetes. Alterations in EXOC8 expression and function can disrupt exocytosis leading to impaired cell signaling pathways that contribute to tumor progression and insulin secretion defects. EXOC8's interactions with proteins like Insulin receptor substrate 1 (IRS1) and Cdc42 highlight its involvement in these pathologies linking cellular transport dysfunctions to disease mechanisms.