Abcam, ab255269, Anti-C15orf41 antibody [EPR21169-28] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal C15orf41 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21169-28,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab255269 is the carrier-free version of
ab215190
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C15orf41 also known as chromosome 15 open reading frame 41 is a protein with a molecular mass of approximately 38 kDa. This protein is expressed widely in various tissues showing higher expression levels in the liver heart and skeletal muscle. C15orf41 is characterized by its ability to bind nucleic acids suggesting a role in nucleic acid metabolism. The gene encoding C15orf41 is located on chromosome 15 reflecting its name.
Biological function summary
The functions of C15orf41 are closely related to its involvement in DNA replication and repair processes. As part of a larger protein complex C15orf41 plays a role in maintaining genome stability. It assists in the resolution of DNA structures that could otherwise pose challenges during replication. The protein interacts with other DNA repair machinery components ensuring effective genomic maintenance.
Pathways
C15orf41 participates in key biological processes tied to DNA repair and replication stress response pathways. This protein interfaces significantly with the homologous recombination repair pathway working alongside proteins such as BRCA2. Additionally C15orf41 influences the ATRIP-ATR axis which serves to stabilize the replication fork and DNA damage checkpoint activation ensuring proper DNA replication completion.
Alterations in C15orf41 expression or function can contribute to genomic instability-associated conditions. Studies associate this protein with cancer where its dysregulation may result in unchecked cell proliferation owing to ineffective DNA repair. Furthermore C15orf41 has connections to Fanconi anemia pathway components where defects can lead to hematological abnormalities and predisposition to malignancies.