Abcam, ab25939, Anti-c-IAP1 and c-IAP2 antibody

Size: 100µg
Rabbit Polyclonal c-IAP1 and c-IAP2 antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human BIRC2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BIRC2. The exact immunogen used to generate this antibody is proprietary information.Q13490

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-cIAP Antibody is affinity chromatography purified via peptide column., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C-IAP1 and c-IAP2 also known as cellular inhibitors of apoptosis proteins 1 and 2 are important regulators of apoptosis and inflammation. c-IAP1 has a molecular weight of approximately 70 kDa while c-IAP2 is around 74 kDa. Both proteins are expressed in many tissues including the heart liver and immune cells. They function as E3 ubiquitin ligases where they target specific proteins for ubiquitination leading to proteasomal degradation. This activity plays a significant role in controlling cell survival and inflammation by modulating the levels of key signaling proteins.
Biological function summary
C-IAP1 and c-IAP2 contribute to cell survival by inhibiting apoptosis. They are part of a complex that interacts with other proteins and signaling molecules to regulate the apoptotic machinery. c-IAP1 and c-IAP2 interact with members of the tumor necrosis factor (TNF) receptor-associated factors (TRAFs) family which helps suppress programmed cell death and support cell survival. By doing so they maintain cellular homeostasis and balance between life and death signals in various physiological contexts.
Pathways
C-IAP1 and c-IAP2 are key components in the NF-kB and MAPK signaling pathways. These pathways are important for immune response inflammation and cell survival. c-IAPs interact with TNF receptor 1 (TNFR1) and receptor-interacting protein kinases (RIPKs) modulating downstream effects that activate NF-kB which transcribes genes involved in immune and survival responses. This connectivity highlights the involvement of c-IAP1 and c-IAP2 in pivotal signaling frameworks that coordinate cellular responses under stress and external stimuli.
C-IAP1 and c-IAP2 have significant roles in cancer and chronic inflammatory diseases. They are often overexpressed in various cancers including breast and lung cancer where they contribute to tumorigenesis by preventing cancer cell apoptosis and promoting cell survival. In the context of chronic inflammation these proteins maintain aberrant cell survival contributing to diseases such as rheumatoid arthritis. Connections with proteins like IκB kinase (IKK) highlight their impact on the perpetuation and progression of inflammatory conditions through their modulation of NF-kB signaling.