Abcam, ab259837, Anti-SHARP2/DEC1 antibody [EPR23905-116]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SHARP2/DEC1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23905-116,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SHARP2 also known as DEC1 or BHLHE40 is a basic helix-loop-helix transcription factor with a molecular weight of approximately 39 kDa. This protein primarily regulates gene expression by binding to E-box sequences in the promoter regions of target genes. SHARP2/DEC1 expression occurs in various tissues such as the brain heart and lungs indicating its involvement in diverse physiological processes. The protein functions as a repressor and modulator of different genes linked to development and cellular responses to environmental changes.
Biological function summary
This transcription factor plays a significant role in the regulation of circadian rhythms and cell cycle progression. SHARP2/DEC1 interacts with various proteins to form complexes that influence cell differentiation and proliferation showing its critical function in maintaining cellular homeostasis. The protein also participates in hypoxia response being upregulated under low oxygen conditions which points to its adaptability and function under stress.
Pathways
SHARP2/DEC1 is an important component of the circadian clock and hypoxia signaling pathways. It modulates the activity of other clock genes and interacts with the PER and CRY protein families adding precision to circadian regulation. In the hypoxia pathway SHARP2/DEC1 activity affects the expression of genes involved in cellular adaptation to low oxygen levels cooperating with hypoxia-inducible factors to maintain balance during such conditions.
Changes in SHARP2/DEC1 expression link to cancer and metabolic syndromes. Elevated levels of this protein associate with aggressive tumor growth in different cancers highlighting its potential as a biomarker for tumor progression. Moreover SHARP2/DEC1 involvement in metabolic pathways shows its connection to disorders like obesity and diabetes. This protein's interaction with p53 in cancer pathways further portrays its influence on cell survival and apoptosis making it a significant target for therapeutic research.