Abcam, ab262939, Anti-FATP3 antibody

Size: 100µL
Rabbit Polyclonal FATP3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC27A3 aa 50-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC27A3 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.Q5K4L6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FATP3 protein also called SLC27A3 functions as an acyl-CoA synthetase involved in the uptake and activation of long-chain fatty acids. It has a molecular mass of approximately 79 kDa. FATP3 is primarily expressed in tissues such as the heart liver and adipose tissues suggesting its role in energy metabolism. Its function involves the import and subsequent esterification of fatty acids an essential step in lipid metabolism.
Biological function summary
FATP3 plays an important role in energy homeostasis by facilitating fatty acid transport and activation. It operates as part of a multiprotein complex localized to the mitochondria-associated endoplasmic reticulum membrane. This complex supports the synthesis and turnover of cellular lipids by integrating fatty acids into pathways for triglyceride and phospholipid synthesis highlighting its role in managing cellular lipid stores and membrane composition.
Pathways
FATP3 mediates coordination between lipid transport and metabolism within fatty acid oxidation and biosynthesis pathways. Key pathways include the beta-oxidation pathway where fatty acids are degraded to produce energy and the phospholipid biosynthesis pathway important for membrane formation. FATP3 interacts with proteins such as acyl-CoA dehydrogenase and diacylglycerol acyltransferase aiding in lipid synthesis and metabolism.
FATP3 has been linked to conditions such as metabolic syndrome and type 2 diabetes where fatty acid metabolism is disrupted. The protein interacts with enzymes like lipoprotein lipase which regulates lipid levels. Abnormal FATP3 activity could lead to altered cholesterol and triglyceride levels contributing to the pathogenesis of these metabolic disorders. Understanding FATP3’s function may provide insight into therapeutic targets for managing such diseases.