Abcam, ab263463, Synaptic Marker (Synaptophysin, Synapsin1, PSD95, VAMP2) Antibody Sampler Panel - Human, Mouse

Size: 1Kit
Synaptic Marker sampler panel containing 6 antibodies against Synaptophysin, Synapsin1, PSD95 and VAMP2 - Provided as a sampler panel to allow you to easily evaluate each in your required applications.
Key facts
Reacts with:Mouse, Human,
Target:SYPSee target data

Product details:
Product Specifications
Synaptic Marker (Synaptophysin, Synapsin1, PSD95, VAMP2) Antibody Sampler Panel - Human, Mouse (ab263463) is a panel of 6 monoclonal antibodies to synaptic markers. Synaptic markers are proteins to help identify and study synapses, the junctions between neurons.
This panel contains 5 rabbit recombinant monoclonal antibodies and 1 mouse monoclonal antibody to Synaptophysin (UniProt: P08247), Synapsin I (UniProt: O88935), PSD95 (UniProt: P78352), PSD95 (UniProt: Q62108) and VAMP2 (UniProt: P63027) in convenient trial sizes (20 µg/ 20 µL) to allow for efficient and cost-effect testing of the antibodies simultaneously.
The individual antibodies included in this panel are:
Rabbit recombinant monoclonal anti-Synaptophysin antibody [YE269] (
ab32127
Rabbit recombinant monoclonal anti-Synaptophysin antibody [EP1098Y] (
ab52636
Rabbit recombinant monoclonal anti-Synapsin I antibody [EPR23531-50] - Synaptic Marker (
ab254349
Mouse monoclonal anti-PSD95 antibody [K28/43] - Synaptic Marker (
ab192757
Rabbit recombinant monoclonal anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (
ab238135
Rabbit recombinant monoclonal anti-VAMP2 antibody [EPR12790] (
ab181869
All of these component antibodies are available for purchase individually using their corresponding abIDs.
Quality and Validation
Abcams high quality validation processes ensure each component antibody is sensitive and specific to the target protein.
All antibodies in this panel have been validated in human, mouse and rat samples in a variety of applications, and some also have reactivity in other species.
For information on the species reactivity and application validation of each antibody within the panel, please consult the individual datasheet for each antibody. Suggested dilution factor and additional information on protocols can also be found on the antibody datasheets.
All antibodies in this panel have been cited in peer-reviewed journals and are trusted by scientific community.
Related Products
Many of our antibody clones are also available as carrier-free formulations for easy conjugation to labels of your choice, or in pre-conjugated formats. Please search the clone name for alternative formulations and related products.
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synapsin I Synaptophysin PSD95 and VAMP2 are important proteins in neuronal function. Synapsin I also known as neuron-specific phosphoprotein typically has a mass of approximately 70 kDa and is expressed in nerve terminals. Synaptophysin a major synaptic vesicle protein with a mass around 38 kDa is expressed in presynaptic vesicles. PSD95 a member of the membrane-associated guanylate kinase (MAGUK) family is found in the postsynaptic density of neurons. VAMP2 often referred to as synaptobrevin is found in synaptic vesicles with a mass close to 18 kDa. These proteins play roles as presynaptic and postsynaptic markers critical for synaptic signaling.
Biological function summary
These proteins contribute significantly to neuronal communication. Synapsin I participates in synaptic vesicle dynamics linking synaptic vesicles to the actin cytoskeleton. As part of a larger complex synaptophysin regulates synaptic vesicle fusion and neurotransmitter release. PSD95 is an essential component of the postsynaptic density complex interacting with NMDA receptors and ensuring receptor clustering at synaptic junctions. VAMP2 is involved in the SNARE complex which is pivotal for the fusion of synaptic vesicles with the presynaptic membrane facilitating neurotransmitter release into the synaptic cleft.
Pathways
These proteins integrate into critical synaptic and signaling pathways. Synapsin I influences the regulation of synaptic vesicle pools affecting the availability of neurotransmitters for release during signaling. In the SNARE complex VAMP2 interacts with SNAP-25 and syntaxin to mediate vesicle docking and fusion. Synaptophysin and PSD95 have roles in the glutamatergic synapse pathway cooperating with other proteins to modulate synaptic strength and plasticity. These interactions help maintain synaptic efficiency vital for cognitive processing and neuroplasticity.
These synaptic proteins are linked to neurological and psychiatric conditions. Synapsin I aligns with epilepsy where its dysfunction may lead to altered synaptic activity and uncontrolled neuronal firing. Synaptophysin abnormalities associate with schizophrenia possibly through disrupted neurotransmitter release or altered vesicle cycling. PSD95 correlations with Alzheimer’s disease arise due to its connection with amyloid-beta and synaptic degradation. VAMP2 plays a role in these disorders through its participation in synaptic vesicle trafficking and neurotransmitter release mechanisms. These proteins are focal points in understanding and targeting these neurological conditions.