Abcam, ab264032, Anti-beta Amyloid 1-37 antibody [IBR-9-16-4]

Size: 20µg / 100µg / 1mg
Rabbit Recombinant Monoclonal Amyloid-beta precursor protein antibody. Suitable for WB, Dot, I-ELISA and reacts with Human, Recombinant full length protein - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:IBR-9-16-4,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Dot, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Amyloid 1-37 also known as Aβ1-37 represents a variant of amyloid beta peptides. It has a molecular weight of approximately 4 kDa. The peptide arises as a cleavage product from the amyloid precursor protein (APP). Expression primarily occurs in the central nervous system specifically in brain tissue. Beta amyloid peptides including Aβ1-37 play a role in forming amyloid fibrils that can aggregate into plaques.
Biological function summary
Aβ1-37 participates in the protein aggregation process related to neuronal function. It interacts as part of the larger amyloid beta protein complex. These complexes play roles in synaptic modulation and neuronal plasticity. Aβ peptides like Aβ1-37 contribute to normal brain function but their misprocessing leads to aggregation. Disruption in their function can impact cell signaling pathways.
Pathways
Amyloid beta fragments have key roles in the amyloidogenic pathway. They specifically contribute to the pathway by participating in APP metabolism. Interaction with proteins such as presenilins influences cleavage activity that generates different Aβ isoforms. The Wnt signaling pathway also connects with amyloid beta peptides where they affect downstream effects on cell cycle and synaptic regulation.
Beta amyloid peptides including Aβ1-37 associate strongly with Alzheimer's disease. Accumulation in the brain appears as one of the hallmark pathologies of this neurodegenerative disorder. The peptides also show a relation to cerebral amyloid angiopathy where amyloid deposits within vascular structures. Aβ1-37 and its related fragments interact not only with APP but also with tau protein contributing to further disease progression.