Abcam, ab264140, Anti-G protein beta subunit like/GBL antibody

Size: 100µg
Rabbit Polyclonal G protein beta subunit like/GBL antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MLST8 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MLST8 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BVC4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The G protein beta subunit-like protein often known as GBL is an essential component in cellular signaling. It plays a mechanical role as part of the larger G protein complex that transduces signals from cell surface receptors to intracellular pathways. Though we do not have a precise molecular weight for GBL it is known to interact closely with other subunits of the G protein complex. GBL is widely expressed across various tissues reflecting its involvement in numerous cellular processes.
Biological function summary
GBL contributes to the regulation and setting up of signal transduction pathways by forming a part of the G protein complex. This complex involves the alpha beta and gamma subunits where GBL typically interacts with the beta subunit family. By binding to receptors like GPCRs GBL facilitates the exchange of GDP for GTP on the G protein alpha subunit thereby activating downstream effectors. The complex is critical in ensuring precise cellular responses and GBL maintains structural integrity within it.
Pathways
GBL plays an integral role in the G protein-coupled receptor (GPCR) signaling and the MAPK signaling pathways. In GPCR signaling GBL's interaction with the beta subunit influences processes like sensory perception and cell growth. In the MAPK pathway critical for cell responses to growth signals GBL connects with proteins such as RAF and MEK supporting the cascade of phosphorylation events critical for pathway progression. These pathways highlight GBL's importance in cellular dynamics and network interactions.
Scientists associate GBL with certain cancers and metabolic disorders. Aberrant expression or dysfunction of GBL can lead to disrupted signal transduction an important feature in pathways involved in tumorigenesis such as those involving GPCR signaling anomalies. Additionally the MAPK pathway's misregulation where GBL plays a part links to metabolic disorders. This makes GBL a potential therapeutic target offering insights into developing treatments by targeting associated proteins like GPCRs and components of the MAPK pathway.