Abcam, ab264153, Anti-TPR antibody

Size: 100µL
Rabbit Polyclonal TPR antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Nucleoprotein TPR aa 2300-2350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Nucleoprotein TPR aa 2300-2350. The exact immunogen used to generate this antibody is proprietary information.P12270

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The translocated promoter region protein (TPR) also known commonly as 'horse TPR' consists of approximately 267 kDa. TPR is a nucleoporin protein primarily expressed in the nuclear envelope of eukaryotic cells. It serves as a structural and regulatory component of the nuclear pore complex (NPC) playing a critical role in nucleocytoplasmic transport. A structural scaffold TPR facilitates the organization and entrance of nuclear transport receptors and cargo molecules through the NPC impacting the efficient movement of proteins and RNA across the nuclear membrane.
Biological function summary
TPR interacts with other nucleoporins within the NPC to ensure proper nuclear function. TPR is integral in maintaining the spatial organization and transport selectivity within the nucleoplasm-cytoplasm interface by forming an interaction network with other proteins like NUP98 and NUP153. TPR functions as part of the NPC assembly contributing to essential cellular processes like gene expression regulation and DNA repair by participating in chromatin organization.
Pathways
TPR integrates into the nuclear transport pathway and it also plays a role in the MAPK signaling pathway. Within the nuclear transport pathway TPR facilitates the proper translocation of molecules necessary for downstream cellular functions. In the MAPK signaling pathway it synchronizes with other proteins like ERK to control processes such as proliferation and differentiation. TPR's interaction with these pathways positions it as an important player in cellular communication and response.
TPR has connections to cancer and neurodegenerative diseases. In various cancers abnormal TPR function impacts cell growth and proliferation by altering nuclear transport dynamics. Additionally it associates with Alzheimer's disease through its interactions with tau protein affecting neuronal function. These connections make TPR a significant target for understanding disease mechanisms and developing therapeutic interventions.