Abcam, ab264188, Anti-NCOR2/SMRT antibody

Size: 100µg
Rabbit Polyclonal NCOR2/SMRT antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human NCOR2 aa 1900-2000.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NCOR2 aa 1900-2000. The exact immunogen used to generate this antibody is proprietary information.Q9Y618

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NCOR2 also known as SMRT (Silencing Mediator for Retinoid and Thyroid receptors) is a nuclear receptor co-repressor important in gene regulation. It weighs around 270 kDa and expresses in various tissues including the brain liver and lungs. Mechanically NCOR2 interacts with nuclear receptors and other transcription factors to inhibit gene expression by facilitating the formation of a complex that deacetylates histones causing the chromatin structure to tighten and less transcription to happen.
Biological function summary
This protein functions as part of a large multi-protein complex called the SMRT/N-CoR complex. It acts by binding to un-liganded nuclear receptors such as thyroid hormone receptor and retinoic acid receptor which leads to repression of target genes essential for diverse cellular processes. This regulatory action affects cell growth differentiation and metabolism implicating NCOR2's role in maintaining normal cellular functions.
Pathways
NCOR2 participates in key pathways such as the thyroid hormone signaling pathway and the retinoic acid pathway. These pathways are critical in managing metabolism and development. NCOR2 relates to proteins like histone deacetylases (HDACs) which are part of its repression complex and key to regulating transcription. In these pathways NCOR2's interaction with nuclear receptors directs the outcome of transcriptional activity necessary for proper physiological responses.
Research links NCOR2 to various conditions including acute promyelocytic leukemia (APL) and metabolic disorders. In APL NCOR2 can form part of a fusion protein with retinoic acid receptor-alpha (RARα) disrupting normal gene regulation and promoting cancer. Furthermore its role in transcription repression connects NCOR2 to metabolic dysfunctions suggesting its potential involvement in obesity-related insulin resistance. This relationship is broadened through association with other co-repressor proteins like N-CoR emphasizing the importance of its regulatory function in health and disease.