Abcam, ab264409, Anti-YTHDF1 antibody

Size: 100µL
Rabbit Polyclonal YTHDF1 antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human YTHDF1 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human YTHDF1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9BYJ9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
YTHDF1 also known as YTH domain family protein 1 is a reader protein of N6-methyladenosine (m6A) a common RNA modification. Its mass is approximately 64 kDa. YTHDF1 binds to m6A-modified mRNA and enhances its translation efficiency by recruiting ribosomes. This protein is present in various tissues showing higher expression in brain spleen and lymphoid tissues suggesting a role in development and immunity.
Biological function summary
YTHDF1 affects mRNA stability and translation providing a mechanism for regulating protein synthesis. It operates as part of a complex with other m6A readers like YTHDF2 and YTHDF3 which determine mRNA fate. By promoting translation YTHDF1 impacts cellular responses and adaptation to environmental changes especially during stress and division.
Pathways
YTHDF1 integrates into the mRNA surveillance pathway and translation regulation. It interacts closely with other components such as eukaryotic initiation factors (eIFs) to modulate protein synthesis dynamics. This allows cells to rapidly adjust protein levels in response to cues and maintain homeostasis. Its role is critical in link to ribosomal function and stability of gene expression networks.
YTHDF1 has connections to cancer and neurological disorders. In cancer abnormal YTHDF1 expression associates with tumor progression and metastasis and interacts with proteins like METTL3 involved in m6A deposition. In neurological disorders dysregulation of YTHDF1 influences mRNA translation tied to cognitive functions possibly interacting with neurotransmitter pathways. Understanding these roles shows potential for YTHDF1 as a therapeutic target.