Abcam, ab265104, Human LRRC41 knockout HeLa cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
LRRC41 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp deletion in exon 1,
Disease:Adenocarcinoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-LRRC41, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LRRC41 protein also known as LRR41 or Leucine-Rich Repeat Containing Protein 41 has distinct mechanical roles in cellular processes. Structurally this protein consists of several leucine-rich repeats that facilitate protein-protein interactions. It has a molecular mass of approximately 59 kDa. LRRC41 is widely expressed in human tissues especially in the brain and heart indicating a broad functional importance in these areas.
Biological function summary
LRRC41 plays an essential role in cellular signaling and regulation. It may function as part of larger protein complexes facilitating various regulatory functions. The protein contributes significantly to the regulation of cell cycle and apoptosis among other cellular processes. Its interactions within the cell modulate the signaling pathways that control these vital processes enabling the cell to respond to different stimuli effectively.
Pathways
The LRRC41 protein is involved in the modulation of the MAPK signaling pathway. This pathway is important for transducing extracellular signals into intracellular responses and it is important in cell growth and differentiation. LRRC41 interacts with proteins within this pathway such as RAF1 and MEK to influence signal transduction events. Its involvement in these pathways highlights its role in maintaining cellular homeostasis and responding to environmental changes.
LRRC41 has been implicated in various conditions including cancer and neurodegenerative disorders. In cancer its altered expression can affect cell proliferation pathways linking it to the progression of certain tumors. In neurodegenerative diseases LRRC41 may interact with proteins involved in cellular stress responses such as huntingtin in Huntington's disease. These associations emphasize the relevance of LRRC41 in both research and clinical settings as understanding its role could lead to therapeutic advancements.