Abcam, ab266090, Human TMEM160 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
TMEM160 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 25 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 25 bp deletion in exon 1

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-TMEM160, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM160 also known as transmembrane protein 160 has a mass of approximately 22 kDa. It primarily functions as a transmembrane protein embedded in the cell membrane. TMEM160 shows expression in various tissues particularly in adipose tissue and to some extent in other cell types. Its specific mechanical function is currently not fully defined but it likely involves interactions with lipid components in the cellular membranes.
Biological function summary
Transmembrane protein 160 might play a role in energy homeostasis and metabolic processes. Though not part of a larger complex its expression patterns suggest possible involvement in pathways regulating energy storage and release. Further studies are necessary to identify the specific physiological processes and interactions in which TMEM160 participates.
Pathways
TMEM160 links to processes related to energy metabolism and cellular signaling. It interacts with pathways such as the insulin receptor signaling pathway. Research indicates its relationship with proteins like insulin receptor substrate (IRS) proteins which are central to glucose uptake and utilization processes.
TMEM160 has been implicated in metabolic disorders particularly obesity and type 2 diabetes. The protein's expression and function suggest a role in these conditions possibly through its interaction with insulin-like proteins and glucose transporters which are critical in managing blood glucose levels and energy storage. Further exploration into its role could provide insights into therapeutic targets for these metabolic diseases.