Abcam, ab266205, Human ZNF593 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
ZNF593 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 17 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 17 bp deletion in exon 1

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-ZNF593, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF593 also known as Zinc Finger Protein 593 is a protein with a mass of approximately 30 kDa. It functions as a transcriptional regulator modulating gene expression through binding DNA. ZNF593 is expressed mainly in the nucleus of cells with a concentration in tissues such as the liver kidney and heart. Its zinc finger motif suggests a role in DNA binding and regulatory functions.
Biological function summary
ZNF593 is essential in managing the transcriptional activities within cells. It associates with a multiprotein complex interacting with other proteins to influence transcription. This protein plays a role in regulating cell proliferation and differentiation impacting how cells specialize and grow. Its involvement in interaction with RNA polymerase II highlights its role in gene expression regulation making it important in managing various cellular processes.
Pathways
This protein enhances our understanding of cellular signaling and communication. ZNF593 is involved in the MAPK/ERK and JAK/STAT signaling pathways. These pathways control essential processes like cell growth differentiation and response to external stimuli. ZNF593 interacts directly with key proteins within these pathways such as ERK and STAT which further supports its role in modulating cell fate decisions and signaling cascades.
ZNF593's deregulation links to certain cancers and developmental disorders. Abnormal expression of ZNF593 correlates with progression in liver cancer where it impacts cell proliferation and survival. In addition mutations affecting ZNF593 have been associated with intellectual disabilities. Its interaction with proteins like STAT in these contexts underlines its pathological significance emphasizing the importance of proper regulation for maintaining cellular health.