Abcam, ab266218, Human C19orf24 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
FAM174C KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: Insertion of the selection cassette in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: Insertion of the selection cassette in exon 1

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-FAM174C, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C19orf24 also known as C19orf71 or Chromosome 19 Open Reading Frame 24 is a protein that participates in key cellular mechanisms. This protein weighs approximately 13 kDa. It is primarily expressed in several tissues including the liver lung and spleen. Its exact mechanical role remains under investigation but current research indicates that it plays important roles in cellular signaling and regulatory functions.
Biological function summary
The protein encoded by C19orf24 has interactions that suggest roles in cellular and molecular processes. It is not part of a known larger protein complex. Evidence suggests involvement in cytokine signaling and response making it an interesting target for studies focused on immune response and inflammation. The identification of specific binding partners remains an ongoing area of research as understanding these interactions could clarify its biological roles further.
Pathways
Multiple cytokine mediated signaling pathways involve C19orf24 especially in relation to immune system regulation. It contributes to key pathways like the IL-6 signaling which is important for inflammatory response and possibly interacts with related proteins such as STAT3 a well-known signaling molecule in immune reactions. Continued mapping of these pathways will help elucidate the broader impact of C19orf24 on cellular functions.
Current studies connect C19orf24 to autoimmune conditions and inflammatory disorders such as rheumatoid arthritis. The protein's potential interaction with cytokine pathways and proteins like TNF-alpha which play significant roles in inflammatory responses hints at its contribution to these diseases. Further examination is required to fully understand C19orf24's impact on disease progression and its potential as a therapeutic target.