Abcam, ab266386, Human ATRAID (C2orf28) knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
ATRAID KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 11 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 11 bp deletion in exon 2

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-ATRAID, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C2orf28 also called FLJ20492 is a protein encoded by a gene on chromosome 2 open reading frame 28. This protein has a molecular mass of approximately 20 kDa. It is chiefly expressed in various human tissues including the brain heart and liver. Mechanically C2orf28 interacts with other cellular components although its precise role in cellular processes is not fully defined yet.
Biological function summary
The C2orf28 protein contributes to intracellular signaling and regulatory processes. Although this protein is not widely recognized as part of a complex it participates in maintaining cellular homeostasis which involves a variety of regulatory functions. Due to its expression pattern and regulatory roles it is considered to have an impact at the cellular level.
Pathways
C2orf28 engages in several cell signaling and metabolic pathways. It notably influences pathways related to cellular stress responses and metabolic regulation. The protein may interact with other mediators like AKT1 and MTOR which are essential in these pathways. C2orf28's involvement in such pathways underlines its role in modulating cellular dynamics.
C2orf28 is linked with neurodegenerative conditions and metabolic disorders. Research indicates its potential involvement in Alzheimer's disease due to its expression in the brain and interaction with proteins like tau. Additionally its role in metabolic regulation suggests a connection to disorders such as diabetes where it may interact with proteins involved in insulin signaling. Further studies could elucidate the precise mechanisms of these associations.