Abcam, ab266409, Human SSNA1 knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
SSNA1 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 1

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-SSNA1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SSNA1 also known as sperm-specific antigen 1 is a protein that plays a mechanical role in cellular functions. It weighs approximately 16 kDa and is expressed predominantly in testicular tissue but can also find expression in other tissues like the brain. SSNA1 operates by facilitating the polymerization of microtubules which are structures critical for maintaining cell shape and enabling cell division. This protein associates with microtubules within cells suggesting a role in the regulation of cytoskeleton dynamics.
Biological function summary
SSNA1 serves functions beyond those of structural support and microtubule association. It acts as a part of the microtubule-associated complex which is integral in cellular transport and mitosis processes. SSNA1 contributes to intracellular cargo transport by supporting the movement of cargo along the microtubule network. Its association in the microtubule complex emphasizes its significance in maintaining a balance of assembly and disassembly of cellular structures for regular cell functioning and division.
Pathways
SSNA1 plays a role in the cytoskeleton signaling pathway notably by interacting with key regulators such as tubulin and microtubule-associated proteins. It's involved in processes such as cell cycle regulation particularly during mitosis. SSNA1's interaction with these proteins implies a contributory role in checkpoint controls that ensure correct cell division. Additionally SSNA1 has an influence on signal transduction pathways that govern cell shape and motility. It works in conjunction with pathways like the MAPK signaling pathway which is central to cellular responses to stress and proliferative signals.
Alterations in SSNA1 expression or function have links to certain neurological conditions. SSNA1 has an association with neurodegenerative diseases where its interaction with proteins such as tau can influence tauopathy conditions possibly due to its involvement in microtubule stability. Another condition linked to SSNA1 is Klinefelter syndrome where its overexpression or irregular activity can lead to symptoms associated with testicular abnormalities. Further studies can aid in understanding how SSNA1 impacts the pathogenesis of these disorders and might provide insights into potential therapeutic targets.