Abcam, ab266424, Human CMC2 (C16orf61) knockout HEK-293T cell line

Size: 2 x 1000000Cells / vial / 1000000Cells / vial
CMC2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR/Cas9, 10 bp deletion in exon 2 and Insertion of the selection cassette in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 10 bp deletion in exon 2 and Insertion of the selection cassette in exon 2

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-CMC2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C16orf61 also known as Chromosome 16 Open Reading Frame 61 is a protein coded by the C16orf61 gene. It has a molecular mass of approximately 14 kDa. This protein is expressed in many tissues including the liver kidney and brain indicating its widespread role in cellular processes. Its exact mechanical function remains undetermined though researchers continue to explore its role in various cellular contexts.
Biological function summary
C16orf61 appears to have a significant role in cell cycle regulation and cellular growth. It does not currently belong to any known protein complexes but experimental data suggest it might interact with other proteins involved in growth regulation. Active studies investigate how C16orf61 may influence cellular homeostasis and proliferation.
Pathways
Researchers suggest that C16orf61 might interact with the PI3K/AKT signaling pathway an important pathway for cell survival and growth. This protein may also intersect with the Wnt signaling pathway impacting cell fate and embryonic development. Interactions with these pathways indicate potential connections with proteins like AKT1 and beta-catenin highlighting its possible involvement in broader signaling networks.
Studies indicate potential links between C16orf61 and cancer given its role in growth regulation pathways. C16orf61 may influence tumor development or progression through its interactions with proteins like PTEN in the PI3K/AKT pathway. Additionally there is a plausible association with neurodevelopmental disorders potentially through its involvement in the Wnt signaling pathway although this requires further validation.