Abcam, ab269819, GSK503, EZH2 methyltransferase inhibitor

Size: 5mg / 10mg / 50mg
MW 526.7 Da. Potent (IC 50 = nM; K i = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC 50 = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
Key facts
Form:SolidSee storage information,
Molecular weight:526.7 Da,
Molecular formula:C31H38N6O2,
PubChem:67469117,
Nature:Synthetic,
Solubility:Soluble in water to 5 mMSoluble in DMSO to 25 mMSoluble in ethanol to 50 mM,
Biochemical name:N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide,
Biological description:Potent (IC50 = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC50 = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.,
Canonical smiles:CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C(=CN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C)C,
InChi:InChI=1S/C31H38N6O2/c1-19(2)37-18-21(4)29-25(30(38)33-17-26-20(3)13-22(5)34-31(26)39)14-24(15-27(29)37)23-7-8-28(32-16-23)36-11-9-35(6)10-12-36/h7-8,13-16,18-19H,9-12,17H2,1-6H3,(H,33,38)(H,34,39),
InChiKey:HRDQQHUKUIKFHT-UHFFFAOYSA-N,
IUPAC Name:N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindole-4-carboxamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C