Abcam, ab269887, Apomorphine HCl, dopamine agonist

Size: 100mg / 500mg
MW 625.6 Da. Dopamine pan-receptor agonist. Displays anti-Parkinson's activity in vivo . Protects against MPTP-induced neurotoxicity (mouse model).
Key facts
CAS number:314-19-2,
Form:SolidSee storage information,
Molecular weight:625.6 Da,
Molecular formula:C34H38Cl2N2O5,
PubChem:107882,
Nature:Synthetic,
Solubility:Soluble in water to 50 mM,
Biochemical name:Apomorphine hydrochloride hydrate,
Biological description:Dopamine pan-receptor agonist. Displays anti-Parkinson's activity in vivo. Protects against MPTP-induced neurotoxicity (mouse model).,
Canonical smiles:CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.O.Cl.Cl,
Isomeric smiles:CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.O.Cl.Cl,
InChi:InChI=1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1,
InChiKey:CXWQXGNFZLHLHQ-DPFCLETOSA-N,
IUPAC Name:(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;dihydrochloride

Product details:
Solutions in distilled water may be stored at -20°C for up to 1 week.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The proteins and receptors listed include key regulators in cellular and physiological processes. Estrogen Receptors (ER) alpha and beta Androgen Receptor (AR) and Retinoic Acid Receptor alpha are nuclear hormone receptors that mediate the effects of their respective ligands. Aryl Hydrocarbon Receptor (AhR) interacts with environmental toxins Aromatase converts androgens to estrogens and Acetylcholinesterase breaks down acetylcholine at synapses. Known alternately as TSH-R the Thyroid-stimulating hormone receptor plays a role in thyroid function. PPAR gamma 2 and PPAR delta control lipid metabolism ROR gamma and Constitutive Androstane Receptor (CAR) regulate circadian rhythm and xenobiotic metabolism respectively. Gli3 is involved in Hedgehog signaling while Nrf2 and Bile Acid Receptor NR1H4 respond to oxidative stress and regulate bile acid homeostasis. AhR acts as a ligand-activated transcription factor with a molecular mass of roughly 96 kDa and expresses mainly in the liver and lungs.
Biological function summary
These proteins operate within distinct cellular processes yet can interact in shared pathways. ER alpha and beta form dimers influencing gene expression in response to estrogen. AR similarly translocates to the nucleus after activating by testosterone. In immune response and metabolism Nrf2 partners with Keap1 to manage oxidative stress response. AhR forming a complex with the AhR Nuclear Translocator (ARNT) regulates xenobiotic-metabolizing enzymes. Aromatase located mainly in the gonads and brain critically balances sex steroid levels. Acetylcholinesterase while not part of a complex is indispensable for neuromuscular transmission.
Pathways
All these targets serve prominent roles in interconnected biochemical routes. ER and AR are integral in the estrogen and androgen pathways mediating diverse physiological responses. PPAR gamma and delta are central actors in lipogenesis and fatty acid oxidation influencing metabolic syndrome pathways. ROR gamma interacts with the circadian rhythm pathway and metabolic balance. CAR and AhR modulate the xenobiotic degradation pathway coordinating a response to foreign chemicals. The Hedgehog pathway closely links with Gli3 directing developmental processes. Nrf2 involves the antioxidative stress pathway interacting with proteins like Keap1 to safeguard cells against oxidative damage.
These targets reveal their medical relevance. Abnormal ER or AR activity links to breast and prostate cancers due to disrupted hormone signaling. Gli3 and its pathways associate with developmental disorders like Pallister-Hall syndrome. Nrf2 dysregulation connects with chronic obstructive pulmonary disease (COPD) impacted by oxidative stress. Hypertension and metabolic syndrome relate to PPAR dysfunction given its comprehensive role in lipid and glucose metabolism. AhR overactivation can lead to chemical-induced toxicity and tissue damage. Aromatase issues may result in estrogen excess or deficiency impacting fertility and hormone-related conditions.