Abcam, ab270741, Anti-GREB1 antibody

Size: 100µL
Rabbit Polyclonal GREB1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GREB1 aa 600-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GREB1 aa 600-750. The exact immunogen used to generate this antibody is proprietary information.Q4ZG55

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Used the PrEST antigen as affinity ligand., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GREB1 also known as growth regulation by estrogen in breast cancer 1 is a protein with a molecular mass of approximately 216 kDa. This protein is composed of various structural domains that facilitate its interaction with other biomolecules. GREB1 expression mainly occurs in hormone-responsive tissues including breast and prostate tissues and it has been detected in other tissues as well. The regulation of GREB1 expression is known to be tightly controlled by estrogen signals making it an essential component in estrogen-related pathways.
Biological function summary
GREB1 plays a significant role in cell proliferation and differentiation within estrogen-dependent systems. This function connects it to critical physiological processes. GREB1 acts as an estrogen-responsive gene supporting its involvement in cellular growth mechanisms. It functions as part of a larger complex of proteins mediating signals essential for growth particularly in the context of reproductive biology. Its functionality in these processes highlights its relevance in the study of hormonal regulation.
Pathways
GREB1 integrates into the estrogen receptor signaling pathway as well as the PI3K/Akt pathway. These pathways are key in the regulation of cell survival and proliferation. GREB1 interacts with other proteins such as estrogen receptor alpha (ERα) within these signaling cascades reinforcing its function as an essential modulator of cellular responses to hormonal signals. This integration illustrates the broader network of interactions that GREB1 engages with in cellular environments influencing pathophysiological outcomes.
GREB1 is strongly linked to breast cancer and prostate cancer both of which depend on hormonal dynamics for their development and progression. In the case of breast cancer GREB1 operates alongside proteins like the androgen receptor and ERα reflecting its role in tumor growth that is sensitive to hormonal regulation. Understanding GREB1's contribution to these cancers contributes to developing targeted therapeutic approaches highlighting the importance of this protein in clinical oncology research.