Abcam, ab270999, Anti-proCathepsin D antibody [EPR24352-13]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Cathepsin D antibody. Suitable for ICC/IF, IP, Flow Cyt (Intra), WB and reacts with Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24352-13,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:ICC/IF, Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Procathepsin D also known as CTSD is a precursor form of the enzyme Cathepsin D. It has a molecular mass of approximately 52 kDa. Procathepsin D is an aspartic protease expressed mainly in lysosomes but also found in many tissues like liver spleen and the endometrium. Its precursor form undergoes post-translational modification to become active involving the removal of its propeptide segment.
Biological function summary
This protease plays significant roles in protein degradation and processing within lysosomes. Procathepsin D remains part of lysosomal enzyme complexes influencing lysosomal balance and turnover of proteins. It contributes to the regulation of cell growth apoptosis and protein activation. Also it impacts antigen presentation and immunity showing importance in cellular maintenance and function.
Pathways
Procathepsin D participates in the lysosomal degradation pathway impacting autophagy and proteostasis. It interfaces with kinases and caspases routing signaling and apoptosis pathways. Through the lysosomal protein pathway it relates to proteins like Cathepsin B and L which also deal with proteolysis. Procathepsin D's degradation function influences metabolic processes interconnected with the immune response and tissue remodeling.
Procathepsin D shows connections to breast cancer and Alzheimer's disease. Elevated levels have been observed in breast cancer linking it with tumor progression where it may interact with proteins like cathepsin B. In Alzheimer's disease altered procathepsin D activity affects amyloid processing and neuroinflammation associating closely with proteins like amyloid precursor protein (APP) and other cathepsins involved in neurodegenerative processes.