Abcam, ab271292, Anti-TVA antibody [PICA187E]

Size: 100µg / 1mg
Rat Recombinant Monoclonal ENV antibody. Suitable for WB, Flow Cyt (Intra), ICC/IF, IHC-P and reacts with Bird samples. Cited in 1 publication.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:PICA187E,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Bird,
Applications:ICC/IF, IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Tumor Virus A Receptor (TVA) often referred to as Tva or LDLR family member 1 (LDLR1) is a protein that acts as a receptor for specific avian sarcoma and leukosis viruses (ASLV) subgroup A. It has a molecular mass of approximately 47 kDa. TVA is expressed on the surface of cells in various tissues playing a role in viral entry. It belongs to the low-density lipoprotein receptor (LDLR) family which is involved in endocytosis and ligand binding processes.
Biological function summary
TVA acts as part of the viral entry complex facilitating the binding and internalization of certain retroviruses. Through its function as a receptor TVA allows the virus to attach to and penetrate host cells initiating infection. The protein’s role in viral entry makes it important for viral lifecycle progression. TVA does not function in isolation but often works in tandem with other receptors to mediate efficient viral uptake into the host cell.
Pathways
TVA participates in the endocytosis pathway which is integral for the uptake of viruses into cells. This pathway includes other proteins such as clathrin and dynamin which play roles in vesicle formation and membrane scission. TVA's interaction with these components facilitates the internalization and trafficking of viral particles within the host cell aiding in the infection process. The protein is also related to signal transduction pathways that might be hijacked by viruses to sustain their replication inside host cells.
The role of TVA in viral infections positions it as a critical factor in understanding certain leukemias and sarcomas caused by ASLV. The infection process mediated by TVA can lead to cellular transformation and tumorigenesis particularly in avian species. While direct associations with human diseases have not been extensively documented studying TVA's interaction with viral glycoproteins provides insight into similar mechanisms in other retroviral infections including those involving related receptors like LDLR.