Abcam, ab271512, Recombinant Human beta 2 Microglobulin + FCGRT/FCRN protein (Tagged) (Biotin)

Size: 50µg
Recombinant Human beta 2 Microglobulin + FCGRT/FCRN protein (Tagged) (Biotin) is a Human Full Length protein, in the 1 to 119 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE, Size Exclusion Chromatography.
Key facts
Purity:>90% SDS-PAGE,
Expression system:HEK 293 cells,
Tags:Tag free,
Applications:Size Exclusion Chromatography, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Conjugation:Biotin,
Accession:P55899,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 5Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.02% Potassium chloride

Product details:
Enzymatically biotin-labeled using Avi-tag™ technology.
Co-expressed in HEK-293 cells.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta-2 microglobulin (B2M) is a component of the major histocompatibility complex (MHC) class I molecules which are integral to the immune system. It is also associated with the neonatal Fc receptor (FCGRT or FcRn). The B2M protein has a mass of approximately 11.8 kDa. This protein is widely expressed with notable expression in all nucleated cells. In humans the role of B2M includes antigen presentation to T cells and it aids in the stabilization of MHC molecules.
Biological function summary
B2M interacts with the neonatal Fc receptor and is involved in the regulation of IgG antibody levels by extending their half-life. As part of the FcRn complex B2M also aids in the transport of IgG across epithelial barriers such as the intestinal lining in neonatal mammals. This complex plays a significant role in maintaining the homeostasis of IgG antibodies therefore impacting adaptive immunity.
Pathways
B2M participates in antigen processing and presentation. It forms a complex with FCGRT which is critical in the FcRn pathway responsible for the recycling and transcytosis of immunoglobulins. This interaction preserves IgG from lysosomal degradation. Additionally B2M interacts with other proteins like albumin through related pathways highlighting its involvement in protein recycling and homeostasis.
B2M is relevant to several autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Altered B2M levels are indicative of these conditions reflecting immune dysregulation. Higher levels of B2M are also observed in multiple myeloma a disorder featuring malignancies of plasma cells. In these disease contexts B2M often serves as a biomarker alongside elevated levels of IgG or the presence of paraproteins.