Abcam, ab271749, Recombinant human STK33 protein (Active)

Size: 10µg
Recombinant human STK33 protein (Active) is a Human Full Length protein, in the 2 to 514 aa range, expressed in Baculovirus infected Sf9 cells, with >46%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>46% SDS-PAGE,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Specific Activity: ≥10 pmol/min/μgAssay Conditions: Assay was performed using ADP-Glo reagents in Kinase buffer containing 2 mM DTT using MBP substrate (0.1 mg/ml) and 100 μM ATP. Reaction was performed at 30°C for 40 mins.,
Accession:Q9BYT3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.02% Potassium chloride

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STK33 also known as serine/threonine kinase 33 is a nucleic protein kinase with a mass of approximately 59 kDa. The STK33 protein functions by phosphorylating serine and threonine amino acid residues which helps to regulate various cellular processes. It is broadly expressed in different tissues such as the brain lung and liver indicating its widespread importance in cellular functions.
Biological function summary
STK33 plays a role in cell proliferation and survival. While not part of any well-defined complex STK33 affects pathways associated with tumorigenic processes. It supports cellular growth by promoting cell cycle progression and inhibiting apoptosis which can lead to increased cell proliferation. These functions highlight its potential involvement in oncogenic events where dysregulation of cell growth is a common feature.
Pathways
STK33 is involved in the PI3K/AKT signaling pathway an important pathway for cell survival and metabolism. In this context STK33 interacts with proteins such as AKT and mTOR which are key components of the pathway. Additionally STK33 has connections with the MAPK/ERK pathway linking it with proteins like MEK and ERK well-known for their roles in cell proliferation and differentiation.
STK33 frequently associates with various types of cancer including lung and pancreatic cancer. Its role in promoting cell cycle progression and inhibiting apoptosis associates it with tumor survival and growth. In cancer STK33 activity connects with oncogenic proteins like KRAS influencing cancer cell metabolism and proliferation. Understanding STK33's involvement in these pathways and diseases may offer new avenues for targeted therapeutic interventions.