Abcam, ab271776, Recombinant human ZCH11 protein (Tagged)

Size: 50µg
Recombinant human ZCH11 protein (Tagged) is a Human Fragment protein, in the 212 to 1313 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>90% SDS-PAGE,
Expression system:HEK 293 cells,
Tags:DDDDK tag C-Terminus,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Active,
Accession:Q5TAX3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZCH11 also known as Zinc Finger C2H2 11 is a protein that mechanically functions as a transcription factor. It has a molecular mass of approximately 72 kDa. ZCH11 is expressed in various tissues with higher levels observed in the liver and brain. This protein contains zinc finger motifs which help it bind to specific DNA sequences allowing it to influence the transcription of target genes.
Biological function summary
ZCH11 plays an important role in regulating gene expression impacting cellular differentiation and development. It acts as an important element in cellular processes and is often part of larger protein complexes that collaborate to control transcription. Through its function as a transcription factor ZCH11 contributes to the maintenance of cellular homeostasis and is essential for normal cellular function.
Pathways
ZCH11 is actively involved in the Wnt signaling and cell cycle regulation pathways. In the Wnt signaling pathway ZCH11 interacts with proteins such as β-catenin influencing gene expression related to cell proliferation and differentiation. In the context of cell cycle regulation ZCH11 interacts with cyclins and cyclin-dependent kinases ensuring proper progression through various phases of the cell cycle.
ZCH11 has connections to colorectal cancer and neurodegenerative diseases. Abnormal expression of ZCH11 may lead to the dysregulation of the Wnt signaling pathway contributing to the development of colorectal cancer. In neurodegenerative diseases ZCH11 may alter neuronal gene expression potentially leading to disease progression. In these cases ZCH11 shows relationships with proteins like APC (adenomatous polyposis coli) in cancer and tau protein in neurodegenerative conditions.