Abcam, ab272503, Anti-SARS-CoV-2 envelope protein antibody - Coronavirus

Size: 100µg
Rabbit Polyclonal VEMP antibody. Suitable for IHC-P, ELISA and reacts with SARS-CoV-2 samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:SARS-CoV-2,
Applications:IHC-P, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SARS-CoV-2 envelope protein also known as E protein is a small membrane protein with an approximate mass of 8.4 kDa. This protein integrates into the membrane of the virus and plays significant roles during the viral life cycle particularly in assembly and budding. Researchers identified its presence in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) where it participates in the formation of the viral envelope.
Biological function summary
The envelope protein acts as a viroporin forming ion channels that modulate the ionic environment necessary for the virus. It partakes in the viral assembly process and influences virus morphology. E protein also works in a complex with other structural proteins like the membrane (M) protein contributing to the virus's ability to infect host cells. This complex facilitates proper viral particle assembly and release.
Pathways
The envelope protein interacts with various cellular pathways that affect the host's immune response. It modulates pathways involved in inflammasome activation and cytokine production. For instance it affects NLRP3 inflammasome pathway which has close interactions with M protein and other viral components. By disrupting these pathways the envelope protein helps in avoiding host immune detection and promoting viral pathogenicity.
The envelope protein relates to COVID-19 and its associated respiratory syndromes. Its role in the assembly and release of the virus links it to the severe respiratory symptoms seen in COVID-19 patients. Additionally this protein has connections to the host immune response interacting with proteins like the N protein which is involved in modulating severe inflammatory responses observed in COVID-19 cases. This makes the envelope protein a potential target for antiviral therapies and vaccine development.