Abcam, ab272562, Anti-NMES1 antibody

Size: 100µL
Rabbit Polyclonal NMES1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NMES1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NMES1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9C002

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NMES1 also known as NMES1-1 is a protein involved in cellular organization and structural stability. The protein has a molecular mass of approximately 10 kDa and is primarily expressed in muscle tissues particularly in the skeletal muscle. Research shows NMES1's expression in some smooth muscle tissues as well. It has a distinct role in influencing the cellular scaffold due to its ability to interact with cytoskeletal elements. Although research on NMES1 is still developing its interactions suggest a function in maintaining cellular integrity.
Biological function summary
NMES1 influences cellular structure and organization. While it does not typically exist as part of large protein complexes its role in cytoskeletal interactions places it at the core of cellular stability mechanisms. NMES1 interacts with microtubules and actin filaments underpinning the cellular framework essential for muscle contraction and mechanical stress response. These interactions highlight its potential role in cellular processes beyond simple structural support.
Pathways
NMES1 involvement centers on cytoskeletal regulation and muscle contraction processes. It plays a part in the actin cytoskeleton signaling pathway where it interacts with proteins like actin-binding molecules that modulate cellular tension and motility. Additionally NMES1 has connections with muscle-specific signaling pathways like the myogenesis pathway suggesting its participation in muscle cell differentiation and growth. Through these interactions it supports the integration of mechanical signals into biological responses.
NMES1 has implications in muscular dystrophy and muscle degeneration disorders. Dysfunction or abnormal expression of NMES1 can disrupt cellular organization leading to weakened muscle fibers and loss of muscle function. The protein interacts with dystrophin which is a critical component in maintaining muscle cell integrity. Alterations in NMES1 expression or function can exacerbate disease phenotypes emphasizing its potential therapeutic significance in muscle-related conditions.