Abcam, ab272567, Anti-TMEM141 antibody

Size: 100µL
Rabbit Polyclonal TMEM141 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM141 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM141 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96I45

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM141 also known as transmembrane protein 141 is a lesser-known protein with an estimated molecular mass of approximately 36 kDa. This protein is integrated into the membrane playing roles in various cellular processes. Researchers observe its expression in multiple tissues though detailed distribution data remains limited. Current studies aim to better understand its mechanical operations within cellular membranes.
Biological function summary
TMEM141 appears to partake in cellular communication and transport activities. Researchers suggest it may involve membrane-spanning complexes facilitating interactions between intracellular components and extracellular environments. While direct evidence of associated molecular complexes is scant its function posits a possible role in signal transduction or intracellular transport mechanisms that would benefit from such organization.
Pathways
TMEM141 seems to interact within cellular signaling and transport pathways. Although comprehensive mapping remains ongoing some reports indicate interactions with proteins involved in endocytosis and exocytosis pathways. It may work alongside proteins like clathrin or Rab family members to influence these critical cellular processes maintaining cellular homeostasis and response to external stimuli.
Emerging studies hint at TMEM141’s potential link to metabolic diseases and certain cancers. Some investigations connect it to altered metabolic pathways perhaps through its interaction with proteins like PPARs (Peroxisome Proliferator-Activated Receptors) in metabolic syndromes. In oncology alterations in its expression or function could influence cancer cell metabolism or growth though more research is necessary to solidify these connections.