Abcam, ab272580, Anti-ZFAND5 antibody

Size: 100µL
Rabbit Polyclonal ZFAND5 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZFAND5 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZFAND5 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.O76080

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFAND5 also known as ZNF216 is a protein involved mechanically in protein degradation processes. It has a molecular mass of approximately 24 kDa. This protein is known for its expression in various tissues including muscle and liver. ZFAND5 functions as an adaptor that facilitates the recruitment of proteins to proteasomes aiding in the removal of misfolded or damaged proteins within cells.
Biological function summary
ZFAND5 has a significant role in maintaining cellular protein homeostasis. The protein is part of a complex involving the ubiquitin-proteasome system. This complex acts to recognize proteins marked for degradation. By interacting with the proteasome ZFAND5 enhances the degradation process which is essential for cellular health and function. Its activity ensures the smooth turnover of cellular proteins preventing accumulation that can lead to cellular stress.
Pathways
ZFAND5 participates in protein degradation pathways including the ubiquitin-proteasome pathway and the autophagy-lysosome pathway. In the ubiquitin-proteasome pathway ZFAND5 works alongside ubiquitin tagging proteins for destruction. The interplay with other key proteins like ubiquitin ligase highlights its importance in ensuring proteins are correctly degraded and recycled maintaining cellular balance and function.
Aberrant function or expression of ZFAND5 relates to neurodegenerative diseases such as Alzheimer's disease. In Alzheimer's the failing protein degradation can lead to harmful accumulation of proteins like amyloid-beta in which ZFAND5's role becomes critical. Additionally the protein associates with chronic inflammatory disorders where proper protein turnover is disrupted connecting with inflammatory mediators through faulty pathways. Understanding ZFAND5's activity offers insights into tackling these conditions effectively.