Abcam, ab272618, Anti-FANCL antibody

Size: 100µL
Rabbit Polyclonal FANCL antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human FANCL aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FANCL aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9NW38

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FANCL also known as Fanconi anemia group L protein participates in the Fanconi anemia (FA) pathway. It has a molecular mass of about 42 kDa. FANCL expresses in various tissues with notable expression in the bone marrow and blood-forming organs. The protein works mechanically by functioning as an E3 ubiquitin ligase essential for monoubiquitination of FANCD2 and FANCI which is an important step in the FA DNA repair pathway.
Biological function summary
This protein plays a role in DNA damage repair. FANCL is part of a multiprotein FA complex which is responsible for the repair of DNA interstrand crosslinks. The FA complex coordinates the activation and repair processes required to maintain genome stability. It ensures proper cell cycle progression while responding to DNA damage facilitating normal cellular function and development.
Pathways
FANCL is a component of the FA-BRCA pathway and has strong connections with DNA repair processes. This pathway includes interactions with proteins such as BRCA1 and BRCA2 which manage DNA repair to prevent tumorigenesis. FANCL also engages with elements of the homologous recombination repair pathway where it ensures proper DNA repair by managing the ubiquitination processes.
Defects in FANCL relate to Fanconi anemia a genetic disorder marked by bone marrow failure and cancer predisposition. The protein's association with BRCA2 also links to hereditary breast and ovarian cancers. These connections highlight FANCL's significance in maintaining genetic integrity and its potential impact on cancer development when impaired.