Abcam, ab272622, Anti-PSTK antibody

Size: 100µL
Rabbit Polyclonal PSTK antibody. Suitable for IHC-P, ICC and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PSTK aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PSTK aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q8IV42

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSTK also known as phosphoseryl-tRNA kinase is an enzyme with a molecular mass of approximately 33 kDa. It is expressed in various tissues including liver kidney and brain. This enzyme plays an essential mechanical role in selenocysteine biosynthesis specifically catalyzing the phosphorylation of seryl-tRNA an important step in the generation of selenocysteyl-tRNA.
Biological function summary
PSTK is involved in the biosynthesis of the amino acid selenocysteine often referred to as the 21st amino acid due to its incorporation into selenoproteins. These selenoproteins are part of a complex responsible for various cellular functions including antioxidant defence and redox regulation. By contributing to selenoprotein synthesis PSTK supports the maintenance of cellular homeostasis and physiological processes.
Pathways
PSTK participates in the selenocompound metabolism pathway and the aminoacyl-tRNA biosynthesis pathway. It works closely with proteins such as selenophosphate synthetase which provides the selenium donor for the formation of selenocysteine in selenoproteins. PSTK's enzymatic activity ensures the continued synthesis and functionality of these essential selenoproteins marrying its function with broader biochemical pathways pivotal for cellular health.
PSTK has a connection with disorders related to selenium deficiency such as Kashin-Beck disease a form of osteoarthropathy found in selenium-deficient regions. Additionally PSTK may connect to neurodegenerative disorders due to its role in synthesizing selenoproteins like glutathione peroxidases which provide neuroprotective effects. The functional relationship between PSTK and glutathione peroxidases highlights its importance in conditions where oxidative stress is implicated highlighting the need for functional PSTK in maintaining neurological integrity.