Abcam, ab272629, Anti-WW domain binding protein 4 antibody

Size: 100µL
Rabbit Polyclonal WW domain binding protein 4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human WBP4 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human WBP4 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.O75554

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WW domain binding protein 4 (WBP4) also known by alternate names such as WWBP and Topoisomerase I-Interacting Protein (TOI1) is a protein with a mass of approximately 25 kDa. It participates in protein interactions through its WW domain facilitating the assembly of protein complexes involved in various cellular processes. WBP4 expression is relatively widespread observed in several tissues indicating its broad functional role across different cell types.
Biological function summary
WBP4 functions in pre-mRNA splicing events and participates as a component of the splicing machinery. Its interactions with other splicing factors modulate exon-intron recognition and influence the maturation of mRNA. Through these interactions WBP4 contributes to the regulation of gene expression at the transcriptional level influencing cellular functions by controlling the diversity of proteins generated from single genes.
Pathways
WBP4 has significant involvement in the spliceosome pathway where it plays a role in the regulation and assembly of splicing complexes. Additionally its interactions with proteins such as U2AF65 and SF3b1 highlight its importance within the splicing components that regulate RNA processing events. These relations assure proper RNA splicing and subsequent protein synthesis impacting numerous biological processes.
WBP4 associations include implications in cancer particularly in breast cancer where aberrant splicing events can contribute to disease progression. Its involvement with proteins like SF3b1 in the context of cancer highlights the importance of accurate splicing in preventing oncogenic transformations. Furthermore dysregulation of WBP4 has been observed in spinal muscular atrophy where splicing errors lead to motor neuron degeneration demonstrating the critical nature of splicing fidelity in maintaining health.